How do you use a Coloc?
- Read the original papers describing the analysis you are about to perform.
- You probably want to analyze only some region of interest (ROI), there are 2 ways to do that:
- Launch the Coloc 2 plugin from the menu item: Analyze › Colocalization Analysis › Coloc 2.
What is colocalization in genetics? Synonyms: Colocalization. The phenomenon whereby genetic factors at a particular locus are shared between two or more traits (not to be confused with declaring the exact causal variant).
How do you do colocalization analysis?
What is colocalization in GWAS? Colocalization determines whether a single variant is responsible for both GWAS and eQTL signals in a locus. Thus, colocalization requires correctly identifying the causal variant in both studies. Recently, researchers proposed a series of methods6, 12, 13, 14, 15, 16, 17 to integrate GWASs and eQTL studies.